• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >In vitro dissolution and in vivo gamma-scintigraphic evaluation of press-coated salbutamol sulfate tablet
【2h】

In vitro dissolution and in vivo gamma-scintigraphic evaluation of press-coated salbutamol sulfate tablet

机译：压制硫酸沙丁胺醇片的体外溶出度和体内γ闪烁显像评价

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L–1 HCl) and then pH 6.8 buffer solution was examined. Morphological change of the press-coated tablet during in vitro release was recorded with a digital camera. Release of salbutamol sulfate from press-coated tablets was less than 5 % before 3 h and was completed after 8 h in pH 6.8 phosphate buffer solution. In vivo gamma scintigraphy study carried out on healthy men indicated that the designed system released the drug in lower parts of the GI tract after a lag time of 5 hours. The results showed the capability of the system of achieving delayed release of the drug in both in vitro and in vivo gamma scintigraphy studies.
机译：这项研究的目的是研究硫酸沙丁胺醇压制片剂延迟释放的体外和体内性能。在pH 1.2（0.1 mol L–1 HCl），然后在pH 6.8缓冲溶液中，检查了具有PEG 6000 / Eudragit S100共混物（2：1）外层的压制片剂的体外释放行为。用数码相机记录在体外释放过程中压制包衣片剂的形态变化。压制片剂中硫酸沙丁胺醇的释放在3小时之前少于5％，并在pH 6.8磷酸盐缓冲溶液中8小时后完全释放。对健康男性进行的体内伽玛闪烁显像研究表明，设计的系统在滞后5小时后在胃肠道下部释放了该药物。结果显示了该系统在体外和体内γ闪烁显像研究中均能实现药物延迟释放的能力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号